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Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera

While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V. cholerae virulence factor is its neuraminidase (VcN), which release...

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Detalles Bibliográficos
Autores principales: Alisson-Silva, Frederico, Liu, Janet Z., Diaz, Sandra L., Deng, Lingquan, Gareau, Mélanie G., Marchelletta, Ronald, Chen, Xi, Nizet, Victor, Varki, Nissi, Barrett, Kim E., Varki, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023241/
https://www.ncbi.nlm.nih.gov/pubmed/29912959
http://dx.doi.org/10.1371/journal.ppat.1007133