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Stochastic shielding and edge importance for Markov chains with timescale separation

Nerve cells produce electrical impulses (“spikes”) through the coordinated opening and closing of ion channels. Markov processes with voltage-dependent transition rates capture the stochasticity of spike generation at the cost of complex, time-consuming simulations. Schmandt and Galán introduced a n...

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Detalles Bibliográficos
Autores principales: Schmidt, Deena R., Galán, Roberto F., Thomas, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023243/
https://www.ncbi.nlm.nih.gov/pubmed/29912862
http://dx.doi.org/10.1371/journal.pcbi.1006206