BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

In obesity, elevated insulin causes fatty liver by activating the gene encoding SREBP-1c, a transcription factor that enhances fatty acid synthesis. Two transcription factors, LXRα and C/EBPβ, are necessary but not sufficient for insulin induction of hepatic SREBP-1c mRNA. Here, we show that a third...

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Detalles Bibliográficos
Autores principales: Tian, Jing, Wu, Jiaxi, Chen, Xiang, Guo, Tong, Chen, Zhijian J, Goldstein, Joseph L, Brown, Michael S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023608/
https://www.ncbi.nlm.nih.gov/pubmed/29952285
http://dx.doi.org/10.7554/eLife.36826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023608/
https://www.ncbi.nlm.nih.gov/pubmed/29952285
http://dx.doi.org/10.7554/eLife.36826

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