A RAS-CaMKKβ-AMPKα2 pathway promotes senescence by licensing post-translational activation of C/EBPβ through a novel 3′UTR mechanism

Oncogene-induced senescence (OIS) is an intrinsic tumor suppression mechanism that requires the p53 and RB pathways and post-translational activation of C/EBPβ through the RAS-ERK cascade. We previously reported that in transformed/proliferating cells, C/EBPβ activation is inhibited by G/U-rich elem...

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Detalles Bibliográficos
Autores principales: Basu, Sandip K., Gonit, Mesfin, Salotti, Jacqueline, Chen, Jiji, Bhat, Atharva, Gorospe, Myriam, Viollet, Benoit, Claffey, Kevin P., Johnson, Peter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023738/
https://www.ncbi.nlm.nih.gov/pubmed/29563610
http://dx.doi.org/10.1038/s41388-018-0190-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023738/
https://www.ncbi.nlm.nih.gov/pubmed/29563610
http://dx.doi.org/10.1038/s41388-018-0190-7

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