Protein kinase A-mediated Phosphorylation Regulates STAT3 Activation and Oncogenic EZH2 Activity

Polycomb Repressive Complex 2 (PRC2) member enhancer of zeste homologue 2 (EZH2) trimethylates histone H3 lysine 27 (H3K27me3), alters chromatin structure and contributes to epigenetic regulation of gene expression in normal and disease processes. Phosphorylation of EZH2 augmented EZH2 oncogenic act...

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Detalles Bibliográficos
Autores principales: Özeş, Ali R., Pulliam, Nick, Ertosun, Mustafa G., Yılmaz, Özlem, Tang, Jessica, Çopuroğlu, Ece, Matei, Daniela, Özeş, Osman N., Nephew, Kenneth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023775/
https://www.ncbi.nlm.nih.gov/pubmed/29576612
http://dx.doi.org/10.1038/s41388-018-0218-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023775/
https://www.ncbi.nlm.nih.gov/pubmed/29576612
http://dx.doi.org/10.1038/s41388-018-0218-z

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