RNA Aptamers Rescue Mitochondrial Dysfunction in a Yeast Model of Huntington’s Disease

Huntington’s disease (HD) is associated with the misfolding and aggregation of mutant huntingtin harboring an elongated polyglutamine stretch at its N terminus. A distinguishing pathological hallmark of HD is mitochondrial dysfunction. Any strategy that can restore the integrity of the mitochondrial...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Kinjal A., Chaudhary, Rajeev K., Roy, Ipsita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023792/
https://www.ncbi.nlm.nih.gov/pubmed/30195782
http://dx.doi.org/10.1016/j.omtn.2018.04.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023792/
https://www.ncbi.nlm.nih.gov/pubmed/30195782
http://dx.doi.org/10.1016/j.omtn.2018.04.010

Ejemplares similares