Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion

URB597 (URB) has therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuronal death. The present study investigated the protective effects of URB on autopahgy and mitophagy in a CCH model as well as the underlying mechanisms. The ultrastructural changes were examined by e...

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Detalles Bibliográficos
Autores principales: Su, Shao-Hua, Wu, Yi-Fang, Wang, Da-Peng, Hai, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023888/
https://www.ncbi.nlm.nih.gov/pubmed/29955058
http://dx.doi.org/10.1038/s41419-018-0755-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023888/
https://www.ncbi.nlm.nih.gov/pubmed/29955058
http://dx.doi.org/10.1038/s41419-018-0755-y

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