Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice

Valine–citrulline linkers are commonly used as enzymatically cleavable linkers for antibody–drug conjugates. While stable in human plasma, these linkers are unstable in mouse plasma due to susceptibility to an extracellular carboxylesterase. This instability often triggers premature release of drugs...

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Detalles Bibliográficos
Autores principales: Anami, Yasuaki, Yamazaki, Chisato M., Xiong, Wei, Gui, Xun, Zhang, Ningyan, An, Zhiqiang, Tsuchikama, Kyoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023893/
https://www.ncbi.nlm.nih.gov/pubmed/29955061
http://dx.doi.org/10.1038/s41467-018-04982-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023893/
https://www.ncbi.nlm.nih.gov/pubmed/29955061
http://dx.doi.org/10.1038/s41467-018-04982-3

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