Identification of strong intron enhancer in the heparanase gene: effect of functional rs4693608 variant on HPSE enhancer activity in hematological and solid malignancies

Heparanase is an endo-β-glucuronidase that specifically cleaves the saccharide chains of heparan sulfate (HS) proteoglycans and releases HS-bound cytokines, chemokines, and bioactive growth-promoting factors. Heparanase plays an important role in the nucleus as part of an active chromatin complex. O...

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Detalles Bibliográficos
Autores principales: Ostrovsky, Olga, Grushchenko-Polaq, Ania Hava, Beider, Katia, Mayorov, Margarita, Canaani, Jonathan, Shimoni, Avichai, Vlodavsky, Israel, Nagler, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023935/
https://www.ncbi.nlm.nih.gov/pubmed/29955035
http://dx.doi.org/10.1038/s41389-018-0060-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023935/
https://www.ncbi.nlm.nih.gov/pubmed/29955035
http://dx.doi.org/10.1038/s41389-018-0060-8

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