Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy

Membranous nephropathy is an immune kidney disease caused by IgG antibodies that form glomerular subepithelial immune complexes. Proteinuria is mediated by complement activation, as a result of podocyte injury by C5b-9, but the role of specific complement pathways is not known. Autoantibodies-mediat...

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Detalles Bibliográficos
Autores principales: Luo, Wentian, Olaru, Florina, Miner, Jeffrey H., Beck, Laurence H., van der Vlag, Johan, Thurman, Joshua M., Borza, Dorin-Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023961/
https://www.ncbi.nlm.nih.gov/pubmed/29988342
http://dx.doi.org/10.3389/fimmu.2018.01433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023961/
https://www.ncbi.nlm.nih.gov/pubmed/29988342
http://dx.doi.org/10.3389/fimmu.2018.01433

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