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The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood br...
Autores principales: | Scalise, Mariafrancesca, Galluccio, Michele, Console, Lara, Pochini, Lorena, Indiveri, Cesare |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023973/ https://www.ncbi.nlm.nih.gov/pubmed/29988369 http://dx.doi.org/10.3389/fchem.2018.00243 |
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