CD19(+)CD24(hi)CD38(hi) B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α

Juvenile dermatomyositis (JDM) is a rare form of childhood autoimmune myositis that presents with proximal muscle weakness and skin rash. B cells are strongly implicated in the pathogenesis of the disease, but the underlying mechanisms are unknown. Therefore, the main objective of our study was to i...

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Detalles Bibliográficos
Autores principales: Piper, Christopher J. M., Wilkinson, Meredyth G. Ll., Deakin, Claire T., Otto, Georg W., Dowle, Stefanie, Duurland, Chantal L., Adams, Stuart, Marasco, Emiliano, Rosser, Elizabeth C., Radziszewska, Anna, Carsetti, Rita, Ioannou, Yiannis, Beales, Philip L., Kelberman, Daniel, Isenberg, David A., Mauri, Claudia, Nistala, Kiran, Wedderburn, Lucy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024011/
https://www.ncbi.nlm.nih.gov/pubmed/29988398
http://dx.doi.org/10.3389/fimmu.2018.01372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024011/
https://www.ncbi.nlm.nih.gov/pubmed/29988398
http://dx.doi.org/10.3389/fimmu.2018.01372

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