Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells

Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion...

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Detalles Bibliográficos
Autores principales: Bao, Xiaoyong, Kolli, Deepthi, Esham, Dana, Velayutham, Thangam S., Casola, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024365/
https://www.ncbi.nlm.nih.gov/pubmed/29789500
http://dx.doi.org/10.3390/v10060278
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author Bao, Xiaoyong
Kolli, Deepthi
Esham, Dana
Velayutham, Thangam S.
Casola, Antonella
author_facet Bao, Xiaoyong
Kolli, Deepthi
Esham, Dana
Velayutham, Thangam S.
Casola, Antonella
author_sort Bao, Xiaoyong
collection PubMed
description Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.
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spelling pubmed-60243652018-07-16 Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells Bao, Xiaoyong Kolli, Deepthi Esham, Dana Velayutham, Thangam S. Casola, Antonella Viruses Article Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses. MDPI 2018-05-23 /pmc/articles/PMC6024365/ /pubmed/29789500 http://dx.doi.org/10.3390/v10060278 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bao, Xiaoyong
Kolli, Deepthi
Esham, Dana
Velayutham, Thangam S.
Casola, Antonella
Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells
title Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells
title_full Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells
title_fullStr Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells
title_full_unstemmed Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells
title_short Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells
title_sort human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024365/
https://www.ncbi.nlm.nih.gov/pubmed/29789500
http://dx.doi.org/10.3390/v10060278
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