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Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin

On the basis of the evolutionary relationship between scorpion toxins targeting K(+) channels (KTxs) and antibacterial defensins (Zhu S., Peigneur S., Gao B., Umetsu Y., Ohki S., Tytgat J. Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function. Mol. Biol....

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Detalles Bibliográficos
Autores principales: Zhang, Shangfei, Gao, Bin, Wang, Xueli, Zhu, Shunyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024585/
https://www.ncbi.nlm.nih.gov/pubmed/29867003
http://dx.doi.org/10.3390/toxins10060227