Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain

The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis. The toxin penetrates target cell membranes and exhibits three distinct biological activities. A population of CyaA conform...

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Detalles Bibliográficos
Autores principales: Bumba, Ladislav, Masin, Jiri, Osickova, Adriana, Osicka, Radim, Sebo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024677/
https://www.ncbi.nlm.nih.gov/pubmed/29914160
http://dx.doi.org/10.3390/toxins10060245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024677/
https://www.ncbi.nlm.nih.gov/pubmed/29914160
http://dx.doi.org/10.3390/toxins10060245

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