Cargando…

Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer

A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant alt...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Young Ae, Lee, Jeonghee, Oh, Jae Hwan, Chang, Hee Jin, Sohn, Dae Kyung, Shin, Aesun, Kim, Jeongseon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024771/
https://www.ncbi.nlm.nih.gov/pubmed/29874787
http://dx.doi.org/10.3390/nu10060724
_version_ 1783336129421901824
author Cho, Young Ae
Lee, Jeonghee
Oh, Jae Hwan
Chang, Hee Jin
Sohn, Dae Kyung
Shin, Aesun
Kim, Jeongseon
author_facet Cho, Young Ae
Lee, Jeonghee
Oh, Jae Hwan
Chang, Hee Jin
Sohn, Dae Kyung
Shin, Aesun
Kim, Jeongseon
author_sort Cho, Young Ae
collection PubMed
description A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65–4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81–14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site.
format Online
Article
Text
id pubmed-6024771
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60247712018-07-08 Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer Cho, Young Ae Lee, Jeonghee Oh, Jae Hwan Chang, Hee Jin Sohn, Dae Kyung Shin, Aesun Kim, Jeongseon Nutrients Article A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65–4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81–14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site. MDPI 2018-06-05 /pmc/articles/PMC6024771/ /pubmed/29874787 http://dx.doi.org/10.3390/nu10060724 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cho, Young Ae
Lee, Jeonghee
Oh, Jae Hwan
Chang, Hee Jin
Sohn, Dae Kyung
Shin, Aesun
Kim, Jeongseon
Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
title Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
title_full Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
title_fullStr Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
title_full_unstemmed Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
title_short Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
title_sort inflammatory dietary pattern, il-17f genetic variant, and the risk of colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024771/
https://www.ncbi.nlm.nih.gov/pubmed/29874787
http://dx.doi.org/10.3390/nu10060724
work_keys_str_mv AT choyoungae inflammatorydietarypatternil17fgeneticvariantandtheriskofcolorectalcancer
AT leejeonghee inflammatorydietarypatternil17fgeneticvariantandtheriskofcolorectalcancer
AT ohjaehwan inflammatorydietarypatternil17fgeneticvariantandtheriskofcolorectalcancer
AT changheejin inflammatorydietarypatternil17fgeneticvariantandtheriskofcolorectalcancer
AT sohndaekyung inflammatorydietarypatternil17fgeneticvariantandtheriskofcolorectalcancer
AT shinaesun inflammatorydietarypatternil17fgeneticvariantandtheriskofcolorectalcancer
AT kimjeongseon inflammatorydietarypatternil17fgeneticvariantandtheriskofcolorectalcancer