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Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant alt...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024771/ https://www.ncbi.nlm.nih.gov/pubmed/29874787 http://dx.doi.org/10.3390/nu10060724 |
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author | Cho, Young Ae Lee, Jeonghee Oh, Jae Hwan Chang, Hee Jin Sohn, Dae Kyung Shin, Aesun Kim, Jeongseon |
author_facet | Cho, Young Ae Lee, Jeonghee Oh, Jae Hwan Chang, Hee Jin Sohn, Dae Kyung Shin, Aesun Kim, Jeongseon |
author_sort | Cho, Young Ae |
collection | PubMed |
description | A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65–4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81–14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site. |
format | Online Article Text |
id | pubmed-6024771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60247712018-07-08 Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer Cho, Young Ae Lee, Jeonghee Oh, Jae Hwan Chang, Hee Jin Sohn, Dae Kyung Shin, Aesun Kim, Jeongseon Nutrients Article A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65–4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81–14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site. MDPI 2018-06-05 /pmc/articles/PMC6024771/ /pubmed/29874787 http://dx.doi.org/10.3390/nu10060724 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cho, Young Ae Lee, Jeonghee Oh, Jae Hwan Chang, Hee Jin Sohn, Dae Kyung Shin, Aesun Kim, Jeongseon Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer |
title | Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer |
title_full | Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer |
title_fullStr | Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer |
title_full_unstemmed | Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer |
title_short | Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer |
title_sort | inflammatory dietary pattern, il-17f genetic variant, and the risk of colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024771/ https://www.ncbi.nlm.nih.gov/pubmed/29874787 http://dx.doi.org/10.3390/nu10060724 |
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