The Cellular p53 Inhibitor MDM2 and the Growth Factor Receptor FLT3 as Biomarkers for Treatment Responses to the MDM2-Inhibitor Idasanutlin and the MEK1 Inhibitor Cobimetinib in Acute Myeloid Leukemia

The tumor suppressor protein p53 is inactivated in a large variety of cancer cells. Cellular p53 inhibitors like the mouse double minute 2 homolog (MDM2) commonly suppress the p53 function in acute myeloid leukemia (AML). Moreover, fms like tyrosine kinase 3 (FLT3) growth factor signaling pathways i...

Descripción completa

Detalles Bibliográficos
Autores principales: Seipel, Katja, Marques, Miguel A. T., Sidler, Corinne, Mueller, Beatrice U., Pabst, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025168/
https://www.ncbi.nlm.nih.gov/pubmed/29857559
http://dx.doi.org/10.3390/cancers10060170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025168/
https://www.ncbi.nlm.nih.gov/pubmed/29857559
http://dx.doi.org/10.3390/cancers10060170

Ejemplares similares