Loss of Cyclin-Dependent Kinase Inhibitor Alters Oncolytic Adenovirus Replication and Promotes More Efficient Virus Production

We elucidate the role of p21/Waf-1, a cyclin-dependent kinase inhibitor, on the oncolytic infection and replication cycle of adenovirus by studying both mRNA and adenoviral proteins expression. We found that infection in the absence of p21 causes a significant increase in adenoviral genomes and late...

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Detalles Bibliográficos
Autores principales: Höti, Naseruddin, Johnson, Tamara Jane, Chowdhury, Wasim H., Rodriguez, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025342/
https://www.ncbi.nlm.nih.gov/pubmed/29914081
http://dx.doi.org/10.3390/cancers10060202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025342/
https://www.ncbi.nlm.nih.gov/pubmed/29914081
http://dx.doi.org/10.3390/cancers10060202

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