Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression

Heteronemin, the most abundant secondary metabolite in the sponge Hippospongia sp., exhibited potent cytotoxic activity against several cancer cell lines. It increased the percentage of apoptotic cells and reactive oxygen species (ROS) in Molt4 cells. The use of ROS scavenger, N-acetyl cysteine (NAC...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Cheng, Lu, Mei-Chin, El-Shazly, Mohamed, Lai, Kuei-Hung, Wu, Tung-Ying, Hsu, Yu-Ming, Lee, Yi-Lun, Liu, Yi-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025351/
https://www.ncbi.nlm.nih.gov/pubmed/29914195
http://dx.doi.org/10.3390/md16060212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025351/
https://www.ncbi.nlm.nih.gov/pubmed/29914195
http://dx.doi.org/10.3390/md16060212

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