Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development

Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2), are key regulators of aggressive spreading and metastasis of cancer cells. While targeted small-molecule inhibitors of FAK and PYK2 have been found to have promising antitumor activity, their clinical long-te...

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Detalles Bibliográficos
Autores principales: Naser, Rayan, Aldehaiman, Abdullah, Díaz-Galicia, Escarlet, Arold, Stefan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025627/
https://www.ncbi.nlm.nih.gov/pubmed/29891810
http://dx.doi.org/10.3390/cancers10060196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025627/
https://www.ncbi.nlm.nih.gov/pubmed/29891810
http://dx.doi.org/10.3390/cancers10060196

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