Resistance of HIV-infected macrophages to CD8 T lymphocyte-mediated killing drives immune activation

CD4(+) T lymphocytes are the principal target of HIV infection, but infected macrophages also contribute to viral pathogenesis. Killing of infected cells by CD8(+) cytotoxic T lymphocytes (CTLs) leads to control of viral replication. Here we demonstrate that CTL killing of macrophages is impaired co...

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Detalles Bibliográficos
Autores principales: Clayton, Kiera L., Collins, David R., Lengieza, Josh, Ghebremichael, Musie, Dotiwala, Farokh, Lieberman, Judy, Walker, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025741/
https://www.ncbi.nlm.nih.gov/pubmed/29670239
http://dx.doi.org/10.1038/s41590-018-0085-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025741/
https://www.ncbi.nlm.nih.gov/pubmed/29670239
http://dx.doi.org/10.1038/s41590-018-0085-3

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