The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation

The activity of Cullin-RING ubiquitin E3 ligases (CRL) is regulated by NEDD8 modification. DCN-like proteins promote Cullin neddylation as scaffold-like E3s. One DCNL, DCNL5, is highly expressed in immune tissue. Here, we provide evidence that DCNL5 may be involved in innate immunity, as it is a dir...

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Detalles Bibliográficos
Autores principales: Thomas, Yann, Scott, Daniel C., Kristariyanto, Yosua Adi, Rinehart, Jesse, Clark, Kristopher, Cohen, Philip, Kurz, Thimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025869/
https://www.ncbi.nlm.nih.gov/pubmed/29958295
http://dx.doi.org/10.1371/journal.pone.0199197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025869/
https://www.ncbi.nlm.nih.gov/pubmed/29958295
http://dx.doi.org/10.1371/journal.pone.0199197

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