Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycoly...

Descripción completa

Detalles Bibliográficos
Autores principales: Bettonville, Marie, d'Aria, Stefania, Weatherly, Kathleen, Porporato, Paolo E, Zhang, Jinyu, Bousbata, Sabrina, Sonveaux, Pierre, Braun, Michel Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025959/
https://www.ncbi.nlm.nih.gov/pubmed/29911570
http://dx.doi.org/10.7554/eLife.30938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025959/
https://www.ncbi.nlm.nih.gov/pubmed/29911570
http://dx.doi.org/10.7554/eLife.30938

Ejemplares similares