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Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycoly...

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Detalles Bibliográficos
Autores principales:	Bettonville, Marie, d'Aria, Stefania, Weatherly, Kathleen, Porporato, Paolo E, Zhang, Jinyu, Bousbata, Sabrina, Sonveaux, Pierre, Braun, Michel Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025959/ https://www.ncbi.nlm.nih.gov/pubmed/29911570 http://dx.doi.org/10.7554/eLife.30938

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