Cargando…

The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene. Here, we add to emerging evidence that all six H3K4 methyltransferases play essential roles in the hematopoietic sys...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidt, Kerstin, Zhang, Qinyu, Tasdogan, Alpaslan, Petzold, Andreas, Dahl, Andreas, Arneth, Borros M, Slany, Robert, Fehling, Hans Jörg, Kranz, Andrea, Stewart, Adrian Francis, Anastassiadis, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025962/
https://www.ncbi.nlm.nih.gov/pubmed/29916805
http://dx.doi.org/10.7554/eLife.27157