Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

OBJECTIVE: To signal, FGF19 and FGF21 require co-receptor βKlotho (KLB) to act in concert with FGF receptors, and yet there is appreciable variance in the C-terminal sequences of these two novel metabolic hormones where binding is believed to be primary. We seek to determine the functional consequen...

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Detalles Bibliográficos
Autores principales: Agrawal, Archita, Parlee, Sebastian, Perez-Tilve, Diego, Li, Pengyun, Pan, Jia, Mroz, Piotr A., Kruse Hansen, Ann Maria, Andersen, Birgitte, Finan, Brian, Kharitonenkov, Alexei, DiMarchi, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026317/
https://www.ncbi.nlm.nih.gov/pubmed/29789271
http://dx.doi.org/10.1016/j.molmet.2018.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026317/
https://www.ncbi.nlm.nih.gov/pubmed/29789271
http://dx.doi.org/10.1016/j.molmet.2018.05.003

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