Endogenous Akt Activity Promotes Virus Entry and Predicts Efficacy of Novel Chimeric Orthopoxvirus in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high recurrence rate and poor prognosis. Here, we describe a novel, chimeric orthopoxvirus (CF33) that efficiently kills TNBC. Cytotoxicity was assayed in vitro in four TNBC cell lines. Viral replication was examined...

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Detalles Bibliográficos
Autores principales: Choi, Audrey H., O’Leary, Michael P., Lu, Jianming, Kim, Sang-In, Fong, Yuman, Chen, Nanhai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026447/
https://www.ncbi.nlm.nih.gov/pubmed/29988465
http://dx.doi.org/10.1016/j.omto.2018.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026447/
https://www.ncbi.nlm.nih.gov/pubmed/29988465
http://dx.doi.org/10.1016/j.omto.2018.04.001

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