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Inhibition of Sarco-Endoplasmic Reticulum Ca(2+) ATPase Extends the Lifespan in C. elegans Worms
The sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) refills the endoplasmic reticulum (ER) with Ca(2+) up to the millimolar range and is therefore the main controller of the ER [Ca(2+)] level ([Ca(2+)](ER)), which has a key role in the modulation of cytosolic Ca(2+) signaling and ER-mitochondria C...
Autores principales: | García-Casas, Paloma, Arias-del-Val, Jessica, Alvarez-Illera, Pilar, Fonteriz, Rosalba I., Montero, Mayte, Alvarez, Javier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026643/ https://www.ncbi.nlm.nih.gov/pubmed/29988547 http://dx.doi.org/10.3389/fphar.2018.00669 |
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