Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice

The GluA1 subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) plays a crucial, but highly selective, role in cognitive function. Here we analyzed AMPAR expression, AMPAR distribution and spatial learning in mice (Gria1(R/R)), expressing the “trafficking compromised...

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Detalles Bibliográficos
Autores principales: Bannerman, David M., Borchardt, Thilo, Jensen, Vidar, Rozov, Andrey, Haj-Yasein, Nadia N., Burnashev, Nail, Zamanillo, Daniel, Bus, Thorsten, Grube, Isabel, Adelmann, Giselind, Rawlins, J. Nicholas P., Sprengel, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026654/
https://www.ncbi.nlm.nih.gov/pubmed/29988555
http://dx.doi.org/10.3389/fnmol.2018.00199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026654/
https://www.ncbi.nlm.nih.gov/pubmed/29988555
http://dx.doi.org/10.3389/fnmol.2018.00199

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