Degradation of histone deacetylase 4 via the TLR4/JAK/STAT1 signaling pathway promotes the acetylation of high mobility group box 1 (HMGB1) in lipopolysaccharide‐activated macrophages

High mobility group box 1 (HMGB1) has been proposed as crucial in the pathogenesis of many diseases including sepsis. Acetylation of HMGB1 prevents its entry into the nucleus and leads to its secretion from the cell where it can trigger inflammation. We hypothesized that histone deacetylase 4 (HDAC4...

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Detalles Bibliográficos
Autores principales: Park, Eun J., Kim, Young M., Kim, Hye J., Chang, Ki C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026695/
https://www.ncbi.nlm.nih.gov/pubmed/29988587
http://dx.doi.org/10.1002/2211-5463.12456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026695/
https://www.ncbi.nlm.nih.gov/pubmed/29988587
http://dx.doi.org/10.1002/2211-5463.12456

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