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Suppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and α‐actinin, linking innate immunity to the cytoskeleton
Suppressor of IKKepsilon (SIKE) is associated with the type I interferon response of the innate immune system through TANK‐binding kinase 1 (TBK1). Originally characterized as an endogenous inhibitor of TBK1 when overexpressed in viral infection and pathological cardiac hypertrophic models, a mechan...
Autores principales: | Sonnenschein, Halie A., Lawrence, Kenneth F., Wittenberg, Karli A., Slykas, Frank A., Dohleman, Emerald L., Knoublauch, Jilan B., Fahey, Sean M., Marshall, Timothy M., Marion, James D., Bell, Jessica K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026704/ https://www.ncbi.nlm.nih.gov/pubmed/29988566 http://dx.doi.org/10.1002/2211-5463.12454 |
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