Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment

Pancreatic acinar cells synthesize, package, and secrete digestive enzymes into the duodenum to aid in nutrient absorption and meet metabolic demands. When exposed to cellular stresses and insults, acinar cells undergo a dedifferentiation process termed acinar–ductal metaplasia (ADM). ADM lesions wi...

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Detalles Bibliográficos
Autores principales: Jakubison, Brad L., Schweickert, Patrick G., Moser, Sarah E., Yang, Yi, Gao, Hongyu, Scully, Kathleen, Itkin‐Ansari, Pamela, Liu, Yunlong, Konieczny, Stephen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026875/
https://www.ncbi.nlm.nih.gov/pubmed/29719936
http://dx.doi.org/10.1002/1878-0261.12314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026875/
https://www.ncbi.nlm.nih.gov/pubmed/29719936
http://dx.doi.org/10.1002/1878-0261.12314

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