Cargando…

Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective

In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majori...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Ai, Benchabane, Hassina, Ahmed, Yashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026893/
https://www.ncbi.nlm.nih.gov/pubmed/29615557
http://dx.doi.org/10.3390/jdb6020008
_version_ 1783336520545992704
author Tian, Ai
Benchabane, Hassina
Ahmed, Yashi
author_facet Tian, Ai
Benchabane, Hassina
Ahmed, Yashi
author_sort Tian, Ai
collection PubMed
description In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology.
format Online
Article
Text
id pubmed-6026893
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60268932018-07-13 Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective Tian, Ai Benchabane, Hassina Ahmed, Yashi J Dev Biol Review In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology. MDPI 2018-03-28 /pmc/articles/PMC6026893/ /pubmed/29615557 http://dx.doi.org/10.3390/jdb6020008 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tian, Ai
Benchabane, Hassina
Ahmed, Yashi
Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
title Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
title_full Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
title_fullStr Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
title_full_unstemmed Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
title_short Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
title_sort wingless/wnt signaling in intestinal development, homeostasis, regeneration and tumorigenesis: a drosophila perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026893/
https://www.ncbi.nlm.nih.gov/pubmed/29615557
http://dx.doi.org/10.3390/jdb6020008
work_keys_str_mv AT tianai winglesswntsignalinginintestinaldevelopmenthomeostasisregenerationandtumorigenesisadrosophilaperspective
AT benchabanehassina winglesswntsignalinginintestinaldevelopmenthomeostasisregenerationandtumorigenesisadrosophilaperspective
AT ahmedyashi winglesswntsignalinginintestinaldevelopmenthomeostasisregenerationandtumorigenesisadrosophilaperspective