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Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majori...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026893/ https://www.ncbi.nlm.nih.gov/pubmed/29615557 http://dx.doi.org/10.3390/jdb6020008 |
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author | Tian, Ai Benchabane, Hassina Ahmed, Yashi |
author_facet | Tian, Ai Benchabane, Hassina Ahmed, Yashi |
author_sort | Tian, Ai |
collection | PubMed |
description | In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology. |
format | Online Article Text |
id | pubmed-6026893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60268932018-07-13 Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective Tian, Ai Benchabane, Hassina Ahmed, Yashi J Dev Biol Review In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology. MDPI 2018-03-28 /pmc/articles/PMC6026893/ /pubmed/29615557 http://dx.doi.org/10.3390/jdb6020008 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tian, Ai Benchabane, Hassina Ahmed, Yashi Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective |
title | Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective |
title_full | Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective |
title_fullStr | Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective |
title_full_unstemmed | Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective |
title_short | Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective |
title_sort | wingless/wnt signaling in intestinal development, homeostasis, regeneration and tumorigenesis: a drosophila perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026893/ https://www.ncbi.nlm.nih.gov/pubmed/29615557 http://dx.doi.org/10.3390/jdb6020008 |
work_keys_str_mv | AT tianai winglesswntsignalinginintestinaldevelopmenthomeostasisregenerationandtumorigenesisadrosophilaperspective AT benchabanehassina winglesswntsignalinginintestinaldevelopmenthomeostasisregenerationandtumorigenesisadrosophilaperspective AT ahmedyashi winglesswntsignalinginintestinaldevelopmenthomeostasisregenerationandtumorigenesisadrosophilaperspective |