Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma

A liquid chromatography–quadrupole time-of-flight (Q-TOF) mass spectrometric method was developed for early-stage research on adalimumab in rats. The method consisted of immunoprecipitation followed by tryptic digestion for sample preparation and LC-QTOF-MS/MS analysis of specific signature peptides...

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Detalles Bibliográficos
Autores principales: Park, Yuri, Kim, Nahye, Choi, Jangmi, Park, Min-Ho, Lee, Byeong ill, Shin, Seok-Ho, Byeon, Jin-Ju, Shin, Young G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026932/
https://www.ncbi.nlm.nih.gov/pubmed/29882925
http://dx.doi.org/10.3390/pharmaceutics10020061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026932/
https://www.ncbi.nlm.nih.gov/pubmed/29882925
http://dx.doi.org/10.3390/pharmaceutics10020061

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