Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma

TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial‐to‐mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self‐renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of TW has not been established throug...

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Detalles Bibliográficos
Autores principales: Mikheev, Andrei M., Mikheeva, Svetlana A., Severs, Liza J., Funk, Cory C., Huang, Lei, McFaline‐Figueroa, José L., Schwensen, Jeanette, Trapnell, Cole, Price, Nathan D., Wong, Stephen, Rostomily, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026950/
https://www.ncbi.nlm.nih.gov/pubmed/29754406
http://dx.doi.org/10.1002/1878-0261.12320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026950/
https://www.ncbi.nlm.nih.gov/pubmed/29754406
http://dx.doi.org/10.1002/1878-0261.12320

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