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Polymer–Surfactant System Based Amorphous Solid Dispersion: Precipitation Inhibition and Bioavailability Enhancement of Itraconazole
The rapid release of poorly water-soluble drugs from amorphous solid dispersion (ASD) is often associated with the generation of supersaturated solution, which provides a strong driving force for precipitation and results in reduced absorption. Precipitation inhibitors, such as polymers and surfacta...
Autores principales: | Feng, Disang, Peng, Tingting, Huang, Zhengwei, Singh, Vikramjeet, Shi, Yin, Wen, Ting, Lu, Ming, Quan, Guilan, Pan, Xin, Wu, Chuanbin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027051/ https://www.ncbi.nlm.nih.gov/pubmed/29695136 http://dx.doi.org/10.3390/pharmaceutics10020053 |
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