Synthesis and Structure-Activity Relationships of (−)-cis-N-Normetazocine-Based LP1 Derivatives

(−)-cis-N-Normetazocine represents a rigid scaffold able to mimic the tyramine moiety of endogenous opioid peptides, and the introduction of different N-substituents influences affinity and efficacy of respective ligands at MOR (mu opioid receptor), DOR (delta opioid receptor), and KOR (kappa opioid...

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Detalles Bibliográficos
Autores principales: Pasquinucci, Lorella, Parenti, Carmela, Amata, Emanuele, Georgoussi, Zafiroula, Pallaki, Paschalina, Camarda, Valeria, Calò, Girolamo, Arena, Emanuela, Montenegro, Lucia, Turnaturi, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027146/
https://www.ncbi.nlm.nih.gov/pubmed/29734749
http://dx.doi.org/10.3390/ph11020040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027146/
https://www.ncbi.nlm.nih.gov/pubmed/29734749
http://dx.doi.org/10.3390/ph11020040

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