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Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations

Ball-milling is usually used to prepare co-amorphous drug–amino acid (AA) mixtures. In this study, co-amorphous drug–AA mixtures were produced using spray-drying, a scalable industrially preferred preparation method. The influence of the solvent type and solvent composition was investigated. Mixture...

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Detalles Bibliográficos
Autores principales: Mishra, Jaya, Rades, Thomas, Löbmann, Korbinian, Grohganz, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027151/
https://www.ncbi.nlm.nih.gov/pubmed/29649124
http://dx.doi.org/10.3390/pharmaceutics10020047