Cargando…

Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure

Nearly half a century has passed since the demonstration that cannabis and its chief psychoactive component Δ(9)-THC lowers intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic target for glaucoma, a condition that places millions at risk of blindness. It is likely tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miller, Sally, Kulkarni, Shashank, Ciesielski, Alex, Nikas, Spyros P., Mackie, Ken, Makriyannis, Alexandros, Straiker, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027315/ https://www.ncbi.nlm.nih.gov/pubmed/29786643 http://dx.doi.org/10.3390/ph11020050

Ejemplares similares

Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model
por: Miller, Sally, et al.
Publicado: (2016)

Chain Substituted Cannabilactones with Selectivity for the CB2 Cannabinoid Receptor
por: Alapafuja, Shakiru O., et al.
Publicado: (2019)

Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats
por: Spyridakos, Dimitris, et al.
Publicado: (2022)

Δ(9)-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure
por: Miller, Sally, et al.
Publicado: (2018)

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner
por: Miller, Sally, et al.
Publicado: (2017)

Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ(8)-Tetrahydrocannabinols
por: Nikas, Spyros P., et al.
Publicado: (2014)

Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure
por: Miller, Sally, et al.
Publicado: (2016)

Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation
por: Thapa, Dinesh, et al.
Publicado: (2020)

A Critical Evaluation of Terpenoid Signaling at Cannabinoid CB1 Receptors in a Neuronal Model
por: Dvorakova, Michaela, et al.
Publicado: (2022)

SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB(1) receptors
por: Dvorakova, Michaela, et al.
Publicado: (2021)

Structural basis for activation of CB1 by an endocannabinoid analog
por: Krishna Kumar, Kaavya, et al.
Publicado: (2023)

Cannabinoid CB1 receptors regulate salivation
por: Andreis, Kelsey, et al.
Publicado: (2022)

Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
por: Jiang, Shuxian, et al.
Publicado: (2007)

THC Regulates Tearing via Cannabinoid CB1 Receptors
por: Thayer, Amanda, et al.
Publicado: (2020)

A peripheral CB(2) cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB(2) reporter mouse
por: Lin, Xiaoyan, et al.
Publicado: (2022)

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
por: Atwood, Brady K, et al.
Publicado: (2011)

Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite
por: Honrao, Chandrashekhar, et al.
Publicado: (2020)

A collection of cannabinoid-related negative findings from autaptic hippocampal neurons
por: Straiker, Alex, et al.
Publicado: (2023)

Corrigendum: Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite
por: Honrao, Chandrashekhar, et al.
Publicado: (2021)

Cannabinoid CB(1) Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity
por: Argueta, Donovan A., et al.
Publicado: (2019)

Targeting the Endocannabinoid System for Neuroprotection: A (19)F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HSA
por: Zhuang, Jianqin, et al.
Publicado: (2013)

PM288. Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction
por: Gardner, Eliot L., et al.
Publicado: (2016)

Cataract Surgery to Lower Intraocular Pressure
por: Berdahl, John P.
Publicado: (2009)

Accommodative Exercises to Lower Intraocular Pressure
por: Stokkermans, Thomas J., et al.
Publicado: (2020)

Effects of a Selective Cannabinoid CB2 Agonist and Antagonist on Intravenous Nicotine Self Administration and Reinstatement of Nicotine Seeking
por: Gamaleddin, Islam, et al.
Publicado: (2012)

Synthesis of Functionalized Cannabilactones
por: Liu, Yingpeng, et al.
Publicado: (2020)

New Therapeutic Targets for Intraocular Pressure Lowering
por: Rocha-Sousa, A., et al.
Publicado: (2013)

Is the observed lowering of intraocular pressure due to treatment?
por: Thomas, Ravi, et al.
Publicado: (2013)

The intraocular pressure-lowering properties of intravenous paracetamol
por: van den Heever, Henning, et al.
Publicado: (2016)

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
por: Kundert, Kale, et al.
Publicado: (2019)

Investigating the Effects of Exogenous and Endogenous 2-Arachidonoylglycerol on Retinal CB1 Cannabinoid Receptors and Reactive Microglia in Naive and Diseased Retina
por: Papadogkonaki, Sofia, et al.
Publicado: (2023)

An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
por: Straiker, Alex, et al.
Publicado: (2021)

Contralateral intraocular pressure lowering effect of prostaglandin analogues
por: Rao, Harsha L., et al.
Publicado: (2014)

SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
por: Durydivka, Oleh, et al.
Publicado: (2023)

Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys
por: Kaneko, Yoshio, et al.
Publicado: (2017)

Cannabinoids Regulate Sensory Processing in Early Olfactory and Visual Neural Circuits
por: Heinbockel, Thomas, et al.
Publicado: (2021)

Peripheral Latanoprost Administration Lowers Intraocular Pressure in the Wistar Rat
por: Świątkiewicz, Maciej, et al.
Publicado: (2020)

The Effect of Intraocular Pressure-Lowering Medication on Metastatic Uveal Melanomas
por: Pals, Jan, et al.
Publicado: (2021)

Effects of the CB1 Receptor Antagonists AM6545 and AM4113 on Insulin Resistance in a High-Fructose High-Salt Rat Model of Metabolic Syndrome
por: Eid, Basma G., et al.
Publicado: (2020)

Effect of prophylactic intraocular pressure-lowering medication (brinzolamide) on intraocular pressure after ranibizumab intravitreal injection: A case–control study
por: Song, Shuang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rmib2comf248u6odg3fa44e1oc