Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization

The 3-trifluoroacetyl–substituted 7-acetamido-2-aryl-5-bromoindoles 5a–h were prepared and evaluated for potential antigrowth effect in vitro against human lung cancer (A549) and cervical cancer (HeLa) cells and for the potential to inhibit tubulin polymerization. The corresponding intermediates, na...

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Detalles Bibliográficos
Autores principales: Mphahlele, Malose J., Parbhoo, Nishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027433/
https://www.ncbi.nlm.nih.gov/pubmed/29891753
http://dx.doi.org/10.3390/ph11020059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027433/
https://www.ncbi.nlm.nih.gov/pubmed/29891753
http://dx.doi.org/10.3390/ph11020059

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