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Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis
PURPOSE: Since electroporation (EP) can increase the permeability of biological membranes, we hypothesized that it offers an opportunity to enhance the transdermal delivery of drugs for intra-articular indications. Our aim was to compare the anti-inflammatory and analgesic efficacy of EP-combined to...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027698/ https://www.ncbi.nlm.nih.gov/pubmed/29983546 http://dx.doi.org/10.2147/DDDT.S161703 |