Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats

GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function has been hypothesized to be beneficial in the treatment of some mental disorders, but behavioral studies have no...

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Detalles Bibliográficos
Autores principales: Kononoff, Jenni, Kallupi, Marsida, Kimbrough, Adam, Conlisk, Dana, de Guglielmo, Giordano, George, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027959/
https://www.ncbi.nlm.nih.gov/pubmed/29971251
http://dx.doi.org/10.1523/ENEURO.0153-18.2018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027959/
https://www.ncbi.nlm.nih.gov/pubmed/29971251
http://dx.doi.org/10.1523/ENEURO.0153-18.2018

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