Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

The human dopamine transporter (hDAT) plays a major role in dopamine homeostasis and regulation of neurotransmission by clearing dopamine from the extracellular space using secondary active transport. Dopamine is an essential monoamine chemical messenger that regulates reward seeking behavior, motor...

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Detalles Bibliográficos
Autores principales: Navratna, Vikas, Tosh, Dilip K., Jacobson, Kenneth A., Gouaux, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028122/
https://www.ncbi.nlm.nih.gov/pubmed/29965988
http://dx.doi.org/10.1371/journal.pone.0200085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028122/
https://www.ncbi.nlm.nih.gov/pubmed/29965988
http://dx.doi.org/10.1371/journal.pone.0200085

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