A model for postzygotic mosaicisms quantifies the allele fraction drift, mutation rate, and contribution to de novo mutations

The allele fraction (AF) distribution, occurrence rate, and evolutionary contribution of postzygotic single-nucleotide mosaicisms (pSNMs) remain largely unknown. In this study, we developed a mathematical model to describe the accumulation and AF drift of pSNMs during the development of multicellula...

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Detalles Bibliográficos
Autores principales: Ye, Adam Yongxin, Dou, Yanmei, Yang, Xiaoxu, Wang, Sheng, Huang, August Yue, Wei, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028137/
https://www.ncbi.nlm.nih.gov/pubmed/29875290
http://dx.doi.org/10.1101/gr.230003.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028137/
https://www.ncbi.nlm.nih.gov/pubmed/29875290
http://dx.doi.org/10.1101/gr.230003.117

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