Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs)

[Image: see text] Dinucleoside phosphoramidites containing a triazole internucleotide linkage flanked by locked nucleic acid (LNA) were synthesized and incorporated into oligonucleotides (ONs). ONs bearing both LNA and triazole at multiple sites were obtained and their biophysical properties includi...

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Detalles Bibliográficos
Autores principales: Kumar, Pawan, Truong, Lynda, Baker, Ysobel Ruth, El-Sagheer, Afaf Helmy, Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028152/
https://www.ncbi.nlm.nih.gov/pubmed/29978149
http://dx.doi.org/10.1021/acsomega.8b01086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028152/
https://www.ncbi.nlm.nih.gov/pubmed/29978149
http://dx.doi.org/10.1021/acsomega.8b01086

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