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Inferring the Probability of the Derived vs. the Ancestral Allelic State at a Polymorphic Site

It is known that the allele ancestral to the variation at a polymorphic site cannot be assigned with certainty, and that the most frequently used method to assign the ancestral state—maximum parsimony—is prone to misinference. Estimates of counts of sites that have a certain number of copies of the...

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Detalles Bibliográficos
Autores principales: Keightley, Peter D., Jackson, Benjamin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028244/
https://www.ncbi.nlm.nih.gov/pubmed/29769282
http://dx.doi.org/10.1534/genetics.118.301120