Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair

Linker histone H1 is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair is unclear. Here, we report that linker histone H1.2 is an essential regulator of ataxia telangiectasia mutated (ATM) activation. We show that H1.2 protects chromati...

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Detalles Bibliográficos
Autores principales: Li, Zhiming, Li, Yinglu, Tang, Ming, Peng, Bin, Lu, Xiaopeng, Yang, Qiaoyan, Zhu, Qian, Hou, Tianyun, Li, Meiting, Liu, Chaohua, Wang, Lina, Xu, Xingzhi, Zhao, Ying, Wang, Haiying, Yang, Yang, Zhu, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028381/
https://www.ncbi.nlm.nih.gov/pubmed/29844578
http://dx.doi.org/10.1038/s41422-018-0048-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028381/
https://www.ncbi.nlm.nih.gov/pubmed/29844578
http://dx.doi.org/10.1038/s41422-018-0048-0

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