Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification

Use of the diabetes type II drug Metformin is associated with a moderately lowered risk of cancer incidence in numerous tumor entities. Studying the molecular changes associated with the tumor-suppressive action of Metformin we found that the oncogene SOX4, which is upregulated in solid tumors and a...

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Detalles Bibliográficos
Autores principales: Melnik, Svitlana, Dvornikov, Dmytro, Müller-Decker, Karin, Depner, Sofia, Stannek, Peter, Meister, Michael, Warth, Arne, Thomas, Michael, Muley, Tomas, Risch, Angela, Plass, Christoph, Klingmüller, Ursula, Niehrs, Christof, Glinka, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028397/
https://www.ncbi.nlm.nih.gov/pubmed/29977599
http://dx.doi.org/10.1038/s41421-018-0033-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028397/
https://www.ncbi.nlm.nih.gov/pubmed/29977599
http://dx.doi.org/10.1038/s41421-018-0033-2

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