Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes

Probing the dynamic control features of biological networks represents a new frontier in capturing the dysregulated pathways in complex diseases. Here, using patient samples obtained from a pancreatic islet transplantation program, we constructed a tissue-specific gene regulatory network and used th...

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Detalles Bibliográficos
Autores principales: Sharma, Amitabh, Halu, Arda, Decano, Julius L., Padi, Megha, Liu, Yang-Yu, Prasad, Rashmi B., Fadista, Joao, Santolini, Marc, Menche, Jörg, Weiss, Scott T., Vidal, Marc, Silverman, Edwin K., Aikawa, Masanori, Barabási, Albert-László, Groop, Leif, Loscalzo, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028434/
https://www.ncbi.nlm.nih.gov/pubmed/29977601
http://dx.doi.org/10.1038/s41540-018-0057-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028434/
https://www.ncbi.nlm.nih.gov/pubmed/29977601
http://dx.doi.org/10.1038/s41540-018-0057-0

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