The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock

The inflammatory cytokine TNFα plays a crucial role in the pathology of many inflammatory and infectious diseases. However, the mechanism underlying TNFα cytotoxicity in these diseases is incompletely understood. Here we report that the pro-apoptotic BCL-2 family member BAD mediates TNFα cytotoxicit...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Jie, Zhang, Hao, Xiang, Jialing, Zhao, Yu, Yuan, Xiang, Sun, Beicheng, Lin, Anning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028455/
https://www.ncbi.nlm.nih.gov/pubmed/29795446
http://dx.doi.org/10.1038/s41422-018-0041-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028455/
https://www.ncbi.nlm.nih.gov/pubmed/29795446
http://dx.doi.org/10.1038/s41422-018-0041-7

Ejemplares similares